![]() ![]() It’s a wonderfully surreal moment that encapsulates the odyssey into madness that is Under the Silver Lake, with Keough’s performance being the icing atop the nonsensical cake. In one of the film’s greatest scenes, Keough unleashes her inner Marilyn Monroe for a replica of her famous nude swimming scene in the movie Something's Got to Give, only for the risqué nature of the scene to be completely turned on its head by a sudden last-minute twist. Despite appearing in only a handful of scenes, the dangerous but alluring charm of Sarah casts a seductive spell over the entire film that gives her a prominent presence from start to finish, with Keough’s performance managing to elevate the ‘girl-next-door’ trope into a far more developed and nuanced character. Starring Andrew Garfield as an aimless 33-year-old living in eastern Los Angeles, Under the Silver Lake sees him descending into the bizarre world of conspiracy theories and the Hollywood elite as he searches for his missing neighbor Sarah, in what will surely become one of Keough’s defining roles. While future seasons ditched Reade to focus on other characters connected to the sex industry, season one remains the show’s standout moment, thanks in part to Keough’s tremendous work.ĭavid Robert Mitchell’s follow-up to It Follows proved to be one of the most polarizing films of the 2010s. Given the subject matter it is safe to say that The Girlfriend Experience was a difficult role for Keough to play, but she approaches the character with the unashamed commitment she deserves and the result is her greatest performance. It’s a dark but captivating look into the controversial topic, avoiding pointless titillation for a mature examination that avoids telling the audience whether Reader’s decision is the right one or not. In the role of Christine Reade, a second-year law student who has just landed an internship at the firm Kirkland & Allen, Keough delves into the world of high-end prostitution as a means of supplementing her dwindling income. Keough’s breakout role came in the anthology television series The Girlfriend Experience, based on the 2009 Steven Soderbergh film of the same name (who served as producer on the show). Keough does an excellent job portraying the internal anguish of Sarah despite the veneer of normality she attempts to keep up, and the result is one of her greatest performances. ![]() ![]() From the way Sarah stares vacantly at Mindy as she tries on a wedding dress, dreaming about a life that will never be, or in the moments where they gaze into the other’s eyes for just a fraction longer than they should, Lovesong is a prime example of why less is more. Lovesong is a film built around the small moments, the things that would be entirely superfluous by themselves but combine to create a mosaic of unimaginable heartbreak. But it soon becomes clear that their relationship goes far deeper than friendship, even if they find themselves relucent to admit it. Sarah, a stay-at-home mom currently in a strained relationship with her husband, decides to take an impromptu road trip with her best friend Mindy ( Jena Malone), whom she has not spoken to for years. The following represents a key selection of her crowning moments.Ī decidedly quieter film than the previous entry, but also one where subtle gestures and fleeting glances continue to take precedent over lengthy dialogue exchanges, Lovesong sees Keough taking on the most emotionally impactful role of her career. This list could easily have featured an entirely different set of performances, an achievement made all the more impressive given the relative newness of her career. The task of narrowing down her most essential performances to just nine is no easy task. ![]() While there was a time when every mention of her name was accompanied by a reference to her grandfather Elvis Presley, Keough is now more than capable of standing on the foundations of her own success, and rightfully so. With a selection of roles ranging from a free-spirited hippie selling magazines across the American Midwest to a terrified mother trying to survive in a post-apocalyptic landscape, she has showcased an impressive level of versatility that has allowed her to appear in some of the most acclaimed films of her era. Ever since her debut as Marie Curie in the 2010 musical biopic The Runaways, Riley Keough has steadily made a name for herself as one of the go-to actors in the independent scene. ![]()
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Whether it’s indoors or outdoors our children’s outdoor furniture made of plastic, is easy to wipe off from any activity or meal. That’s right! We even have children’s outdoor furniture! From hosting tea parties to racing airplanes, the outdoors is made for hours of fun playing, exploring, smiling, and laughing. There’s options for extended tables if you need it occasionally for your guests and when you’re done it’s easy to fold back up, including the chairs! Go for a classic look with our wrought iron patio set with a seat cushion for comfort.ĭining Sets range from 2 chairs to 8 or more chairs, providing all the space you need for your friends and family. A place to have a cup of coffee or tea in the morning to start your day as you watch the sun rise or at night to have a quiet evening. You can get the style, color and materials you want with less maintenance!īistro Sets are perfect for a small space on your balcony or your backyard patio. We have everything you need from tables, chairs, benches, and stools that fit your needs and dreams in any size or shape to fit your outdoor space. Cover or store them away at the end of the season in a cool, dry place like a garage, carport or basement! Outdoor Dining SetsĮnjoy those nightly treats on the balcony under the stars or weekend brunches on the patio in the sunshine and fresh air with IKEA’s outdoor dining solutions. In order to keep your outdoor furniture lasting longer, you can clean them occasionally with mild soap and water or we recommend protecting them with outdoor furniture covers. Steel and wood are heavier and more durable materials that you don’t have to worry about being blown away. Aluminum and plastics are durable, light weight and rust resistant. Depending on the patio furniture you shop for we have a variety of materials they’re made from including aluminum, plastic, plastic rattan, steel, acacia, and eucalyptus. You never have to worry with our low maintenance patio furniture. IKEA has traditional, modern, coastal and more outdoor furniture styles that are durable, made of sustainable material and low maintenance. ![]() ![]() Think of the colors and styles you want for your space whether it’s subtle, vivid or an eye-popping pattern. ![]() The fun part about your outdoor living space is the décor! Have fun with it, make it yours and personalized. If it’s sunny out, maybe an umbrella or gazebo for shade? If it’s night out, maybe outdoor lighting to brighten the space? Another tip is to add additional patio accessories like pillows and rugs to bring your living room outside. Think of comfort including outdoor seat cushions, chairs and benches. Give your family and guests options to feel more comfortable outside. With large spaces, we have a variety of outdoor dining sets and sofa sets with ottomans available! Maybe even try an activity space for the whole family to dine, relax, play or cook. If you have limited space, IKEA offers individual pieces of chairs that fold and stack, small tables and outdoor storage options. Whether you have a small or large space on the balcony or backyard, IKEA has a vast variety of patio furniture to choose from. ![]() What should you consider when buying patio furniture? Dreaming of a nap in the sun? A refreshing beverage or snack with friends? A moment alone in the shade? Your dream is waiting in your own backyard and IKEA is here to help create your dream come true with whatever space you have! With your imagination and our wide outdoor range, your dream is covered, whether it’s about dining, lounging, cooking, gardening, storing, or having laundry, we have it all. ![]() ![]() ![]() Microsoft Office 2021 for Mac LTSC v16.70 VL posted on Febru| under Application, Business, office.Adobe Photoshop 2023 v24.0 posted on Octo| under Adobe, Application, Photography.At your disposal is a collection of parts Posts navigation In KSP you must build a space-worthy craft, capable of flying its crew out into space without killing them. Stellaris 2.6.2 (36947) Explore a vast galaxy full of wonder! Paradox Development Studio, makers of the Crusader Kings and Europa Universalis series Kerbal Space Program 1.9.1 + DLC Parkitect is a business simulation game that charges you with the construction and management of theme parks! Bringing back the best of classic Stellaris 2.6.2 (36947) With a choice of boards, computer opponents and online play, it delivers a first-class Parkitect v1.5g DLC (2018) SparkChess is the only chess game on Mac that puts fun first. With a choice of boards, computer opponents and online play, it delivers SparkChess 14.0.0 Travel across Europe as king of the road, a trucker who delivers important cargo across impressive distances! With dozens of cities to explore from SparkChess 14.0.3 It is inspired by classic cRPG Euro Truck Simulator 2 1.37.1.82s Trudograd is a stand-alone story expansion to ATOM RPG – a turn-based roleplaying game set in post-apocalyptic Soviet Union. The Bloons are back and better than ever! Get ready for a massive 3D tower defense game designed to give you hours and hours of the best strategy Barotrauma 0.9.10 (early access)īarotrauma is a 2D co-op survival horror submarine simulator, inspired by games like FTL: Faster Than Light, Rimworld, Dwarf Fortress and Space ATOM RPG Trudograd 0.5.8 (early access) ![]() Travel across Europe as king of the road, a trucker who delivers important cargo across impressive distances! With dozens of cities to explore Bloons TD 6 Build spaceships tile by tile, create optimal gas conditions Dead Age 2 1.6ĭead Age 2 is a unique combination of survival, management, Rogue-Like events, turn-based combat, classic role-playing game with tons Euro Truck Simulator 2 1.38.1.0 Outwit your enemies in daring turn Space Haven 0.9.0Įmbark on a space voyage with your ragtag crew of civilians in search of a new home. The Sims 2: Super Collection contains all of the award winning content from the original plus the addition of 6 expansion packs and 3 “stuff” packs never before Pathway 1.1.6 (39302)Īdventure into the strange unknown with Pathway, a strategy RPG set in the 1930s great desert wilderness. Other activities in the game include The Sims 2 – Super Collection v1.2.4 Minecraft allows players to build constructions out of textured cubes in a 3D procedurally generated world. Join Red, Chuck, Bomb, Silver and the rest Minecraft Java Edition 1.19 The world’s most famous flock has returned in a new version of the mobile game that took the world by storm. Zen Pinball Party delivers the ultimate pinball experience with carefully crafted tables that are inspired by some of the biggest brands from DreamWorks Angry Birds Reloaded 1.15 ![]() Join Red, Chuck, Bomb, Silver and the rest Zen Pinball Party 1.9.0 Live the life of a Sasquatch and do regular everyday Sasquatch stuff like: – Sneak around campsites – Disguise yourself in human clothing – Eat food from Jetpack Joyride 2 1.4.10īarry returns in a frantic adventure! In this case, he will have new equipment and weapons to fight new enemies and make his way through the laboratory to stop the Angry Birds Reloaded 1.17 ![]() ![]() ![]() You should be able to use the controller to play games after that. Once it finds the controller, the light will turn solid.
![]() ![]() ![]() Try the UK version - but it ain't half as much fun. ![]() Following an unexplained paranormal phenomenon, Elise is stuck, completely alone and out of time. Volví con todo con el formato original de La Noche Paranormal Y GRACIAS A TODOS ESTAMOS NUEVAMENTE EN POP RADIO 101. The game puts you in the shoes of Elise, a woman in her thirties who finds herself in the village of Saint-Exil in an imaginary region reminiscent of Brittany. If you can't separate the two, this is not for you. Broken Pieces is an action-packed investigative and adventure video game set in France. This is a TV show and a pretty damn good one. I love the books too and if I want the books, I read the books. If, like me, you can let go of those expectations and enjoy what it is, rather than what you would like it to be, you might just enjoy it as much as I do. If you are a person who gets terribly upset when a script is not faithful to the source material down to the last semi-colon, this show will make your brain implode. It is its own thing and stands on its own merits, which are many. They have taken the core concept and characters and done something utterly different with it. Nobody has ever come close to doing Douglas Adams justice on screen because the insane intricacy and sheer scale of his stories make it impossible. Yes - I know it's nothing like the books. You should watch this because is is sharp, funny, well written, well acted and engaging on many levels. A friendly spirit to all, GHOST is a women-owned creative agency in Los Angeles that provides scalable livestream and social media solutions to brands and. ![]() ![]() ![]() This monograph summarizes the presentations, conclusions, and recommendations of a panel of experts who reviewed the safety, efficacy, and use of GBCAs for several MRI applications. However, while gadopiclenol may fulfill many, if not all, of the requirements of an ideal MR contrast agent, this agent has not entered clinical practice as of this writing (October 2022), and radiologists must still choose between high-relaxivity and high-stability agents. Food and Drug Administration (FDA) for a wide range of MR imaging applications at reduced dose. Recently, a highly stable, high-relaxivity GBCA, gadopiclenol (Vueway™ Bracco Diagnostics Inc.), 2 was approved by the U.S. 1 Such an agent would potentially permit a reduction in contrast dose, resulting in lower Gd exposure, without sacrificing image quality or diagnostic performance. Ideally, an MR contrast agent would possess both high relaxivity and high stability, rendering moot the need to choose between these two properties for a given MRI application. ![]() For example, more stable macrocyclic GBCAs may be better suited to younger patients or those requiring serial MRI examinations, whereas higher-relaxivity agents may be more appropriate in cases where better diagnostic performance has the potential to impact the diagnosis, prognosis, and/or treatment plan. To this end, risk-benefit analyses should be tailored to each patient. GBCA relaxivity and stability are the key properties to consider when selecting a contrast agent for MRI, and achieving the correct balance between high-quality images and low Gd exposure is a primary aim of radiologists. However, while reducing Gd exposure may decrease the levels of retained Gd, it may also lead to less-than-optimal contrast enhancement and thus sub-optimal diagnostic performance. Although no clinical sequelae resulting from Gd retention have been reported, GBCA guidelines recommend taking measures to reduce patient Gd exposure during MRI examinations. Unfortunately, the discovery that gadolinium (Gd) can be retained in the brain and bodily tissues in patients who have been administered GBCAs has led to widespread concern over their safety. In this perspective article, we will discuss the various intravenous contrast agents used for liver MRI and their ideal utilization.īiliary tree Extracellular contrast agents Gadobenate dimeglumine Gadolinium-based contrast agents Gadoxetate disodium Hepatobiliary contrast agents.Gadolinium-based contrast agents (GBCAs) have been used for decades to enhance the diagnostic performance of magnetic resonance imaging (MRI). Gadoxetate, however, provides less satisfactory dynamic phase images compared to ECAs, particularly during the arterial phase. In the last decade, HBAs, particularly Gadoxetate, have been found useful for characterizing lesions with functioning hepatocytes and more importantly in evaluating the biliary tree. ECAs have been used for decades since their introduction into clinical practice and provide excellent dynamic phase information that is useful in characterizing focal liver lesions. The use of appropriate contrast agents for liver MRI requires knowledge of the clinical situation and question to be answered. Currently, two classes of MRI contrast agents are available for clinical use, namely the extracellular contrast agent (ECA) and the hepatobiliary agent (HBA). Contrast enhanced MRI of the liver provides valuable information in the evaluation of both chronic liver disease and focal liver lesions. ![]() ![]() ![]() There’s no automation to solve tedious manual data entry However, as every Excel template is pre-built, you can’t customize them according to your project needs.įor example, if your stakeholders ask for a particular invoice format and you can’t find it online - you’re done for! C. Oftentimes, a business case may need out-of-the-box thinking.Ĭertain projects are going to be unique with different needs and requirements. Excel templates are difficult to customize Say goodbye to relying on those pre-made templates ! B. Availability of free project management softwareĭ edicated project management tools like ClickUp offer everything you need for effective project management!įrom designing a project management plan and creating a to-do list to keeping an eye on your status report or managing multiple projects - they can help you with anything you need. Here are three reasons why you should consider Excel alternatives to manage projects: A. But remember, these tools were never built for project or task management ! The templates we discussed so far can help you manage your projects in Excel or a Google sheet. Let’s find out why… 3 Reasons Why You Shouldn’t Use Excel for Project Management Using Excel, or even a Google Sheet for project management isn’t the best way to manage any project. This Gantt chart Excel template can be used as a project planner, allowing you to track and synchronize all the activities of a project.ĭownload this Gantt project planner template. Get a big picture overview of a project, visualize dependencies, and get ahead of blockers before they happen with this simple Gantt Chart template.ĭownload this ClickUp simple Gantt Chart template.Ĭheck out more Gantt chart templates! 25. This simple Gantt Chart allows you to create a project schedule and track your progress within Excel.ĭownload this Excel simple Gantt Chart template. ![]() You’ll get access to any project template Excel has, like:īonus: Brand guideline examples Gantt Chart Project Management Templates 23. Open MS Excel, click on the ‘New’ tab and then type ‘project’ in the search bar on the right. ![]() However, it does offer some free project management templates you could use to manage projects easily. Here are some Excel & ClickUp templates that are designed for basic project management: 25 Free Project Management Templatesīefore we highlight some useful templates, note that Excel has some limitations.Įxcel was never built for project management. Let’s get started! What Is a Project Management Template?Ī project management template is a sheet with placeholders that help you document various project activities, like:īut how useful are they in real-life projects? 3 Reasons Why You Shouldn’t Use Excel for Project Management.Graphic Design Project Management Templates.ClickUp Agile Project Management Template Microsoft Word Monthly Status Report Template Microsoft Word Basic Project Status Report Template Microsoft Word Project Timeline with Project Milestones Microsoft Word Daily Work Schedule Template Microsoft Word Weekly Project Schedule Template NYU Microsoft Word Project Charter Template ![]() ![]() ![]() How to Download Spotify Music for djay Pro With it, you can own Spotify music files on your computer and move them to other platforms for use with ease.ĭownload Download Part 2. Also, it can run the conversion in batches and will keep the original quality. Moreover, this tool allows you to alter bit rate, channel and other output parameters for Spotify songs. Then you can put Spotify on djay Pro for mixing without any limits. The converted Spotify tracks are also downloaded as local files and saved on your computer. ![]() This powerful tool will help convert Spotify music to MP3, AAC, WAV, and other universal formats. What you need is an additional tool called DRmare Spotify Music Converter. And it is one of the useful methods after the djay Spotify integration ends. This method is workable for Spotify free users and Spotify Premium users. This part is here to show you how to get Spotify djay Pro to work together. "Is djay Pro Spotify still working?" Yes. How to Get Spotify on djay Pro - Best Solution And then you can make Spotify djay Pro work together on your device. Here you will see how to connect Spotify to djay Pro with the best solution. If you are looking for a way to use Spotify on djay Pro, then you can check out this post. Yet, the djay Pro Spotify integration ended on July 1, 2020. Before, Spotify premium users can use djay Pro with Spotify. With it, you can mix tracks from local device, streaming services and more if you want. ![]() djay Pro is a music mixing app on Windows, Mac, iOS and Android devices. ![]() ![]() ![]() All other authors declare no competing interests. M.H.: Consulting for Takeda Phamaceutical Company, Ono Pharmaceutical and Alfresa Pharma Corporation. G.J.L.: Consulting for Jazz, UCB, Bioprojet and NLS Pharmaceutics, and member of advisory board Jazz, UCB, Bioprojet. There are two types: narcolepsy type 1 (formerly narcolepsy with cataplexy) and narcolepsy type 2 (formerly. Besides EDS, people with narcolepsy type 1 also have cataplexy, which is a sudden but temporary muscle weakness, sometimes brought on by laughter or other. M.T.: Consulting for NLS Pharmaceutics and unrestricted research grant from Jazz Pharmaceuticals. Narcolepsy is a disorder of rapid onset rapid eye movement (REM) sleep characterized by excessive daytime sleepiness (EDS), frequent uncontrollable sleep attacks as well as sleep fragmentation and can be associated with cataplexy, sleep paralysis, and hypnagogic hallucinations. modafinil, armodafinil, stimulants), reducing cataplexy attacks (e.g. People diagnosed with type 1 narcolepsy experience episodes of cataplexy, while people with type 2 narcolepsy do not. ![]() Treatments for narcolepsy are aimed at improving wakefulness (e.g. Our results suggest that HCRT neurons are alive, but epigenetically silenced, in the hypothalamus of narcolepsy patients, opening the possibility to reverse or cure narcolepsy. Narcolepsy is a chronic, disabling neurologic disorder characterised by excessive daytime sleepiness (EDS) and, in up to 60 of patients, cataplexy. Ets1-KO mice display downregulated Hcrt expression, while pax5-ets1 knockdown in zebrafish causes decreased hcrt expression, decreased activity and sleep fragmentation, similar to narcolepsy patients. We show that the human HCRT gene promoter is methylation-sensitive in vitro, and is hypermethylated in the hypothalamus of patients selectively at a putative PAX5:ETS1 binding site within the proximal HCRT promoter. People with this type of narcolepsy experience a strong need to sleep or sudden instances of unplanned sleep daily for at least three months. Research suggests 14 to 36 of people with narcolepsy have narcolepsy type 2. Similar to Hcrt knockout mice, narcolepsy patients show intact hypothalamic QRFP expression, and cerebrospinal fluid levels of QRFP peptide are increased, suggesting their HCRT neurons are intact. Narcolepsy type 2 is similar to narcolepsy type 1 but does not involve cataplexy or low levels of hypocretin-1. In rare cases, cataplexy may precede the development of difficulties in maintaining alertness. Cataplexy usually develops approximately several weeks to months after the development of excessive daytime sleepiness. Here we show that the expression of another hypothalamic neuropeptide, QRFP, is lost in mouse models with HCRT cell-ablation, but tends to be even increased in Hcrt gene knockout mice, suggesting that QRFP expression can be used as a proxy for the presence or absence of HCRT neurons. Some people with narcolepsy do not have cataplexy, and cataplexy is not necessary for a diagnosis of narcolepsy. The condition is believed to result from autoimmune destruction of hypocretin (HCRT) neurons, although direct evidence is lacking and mere Hcrt gene inactivation causes full-blown narcolepsy in mice. ![]() Narcolepsy with cataplexy is a chronic sleep disorder characterized by hypocretin deficiency. ![]() ![]() ![]() You can become a member of the platform and share your views on manga comics. With over 50 million subscribers, Mangakakalot has one of the biggest manga reader communities. To import manga, you do not need to pay or even register. On Mangakakalot, you can get nearly every manga comic for free. This platform attracts over 80 million users a month. Comics are available in 20 different languages including English, Korean, Japanese, Italian, German, etc. This platform serves as a great alternative to Mangakakalot. Mangakakalotįor never-ending collection of manga comics, try Mangakakalot. 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There is a section on top of the website where you can find the list of genres available on MangaOwl. On MangaOwl, you can read manga comics according to their genres. The database of manga comics is frequently updated on this platform, which means the number of manga comics is increasing day by day on MangaOwl. On MangaOwl, you can also share your manga comics with the readers. This is an ad-free platform that brings you the latest chapters of your favourite manga comics. Even a beginner can find and read manga comics without any hassle on MangaOwl. The website has a straightforward and friendly user interface. We are talking about MangaOwl that is a feature-rich manga comics website having a massive library of old and new and popular Manga comics. From romantic to action to sci-fi, you can read a different kind of comics of your choice on these platforms.Īmong all, there is one most popular manga comic platform that holds a huge selection of manga comics in different genres. ![]() There are different types of manga comics available for comics lovers. The internet is full of websites that provide free access to manga comics. These days, people prefer reading their manga comics online. The world is evolving gradually and the way of reading comics is also changing. No matter how old are you, you always enjoy watching your favourite cartoon and comics. We spend our entire childhood watching cartoons and reading comics. ![]() |
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